Manchester City will think the Barcelona defence is vulnerable, although full backs Jordi Alba and Sergi Roberto will be available.
Former Barca captain Guardiola, the Catalan club's most decorated coach with 14 trophies in a scintillating four-year spell, is set for his latest emotional return to the Nou Camp.
But the arrival of the revered Guardiola as manager in the summer could take City to a different level and Barca know full well what their former hero is capable of.
"We are going to play against one of the best teams in the world and we have to see how we respond".
Barcelona cruised past Man City the last time they met in the Champions League in the 2015 Round of 16. Let us know in the comments section below.
Barcelona have won all four of their most-recent meetings with the Citizens in the Champions League and Enrique feels the match against Deportivo was the ideal preparation to extend that run, but he knows they will be a completely different opponent under Pep Guardiola. I think you have to play against the best to see how you can deal with it and it always brings the best out in you as well. The way they play in Germany for example is insert onomatopoeic word here incredible. "It will be hard to get the ball and it it's a good challenge to demonstrate we're still on top".
Enrique was speaking at a press conference to preview the game along with long-serving defender Gerard Pique, who was full of praise for his old manager.
"If it happens, there would be a list of six, seven or eight clubs who would want to sign him, but it will be down to Messi where he wants to go".
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Barcelona are understandably [1.5] favourites to win this but heavy odds-on prices aren't what we're looking for.
Manchester City travel to the Camp Nou this Wednesday evening to face Spanish giants Barcelona in the tie of the Champions League round. The facts of the matter are that we won four titles that year and were playing better than ever, with the 3-4-3 we used against Real Madrid and the 3-7-0 I opted for in the Club World Cup. They create pressure differently, more like us.
Although he has visited the Camp Nou as an opposing manager before, during his time with Bayern Munich, Guardiola has admitted that he is not yet used to the feeling.
Guardiola will be leading Manchester City to the ground where he he became successful and will have to contend with most of the players he tutored while he was still coach with the Baulgrana.
We sat back, contained them and hit them on the counter-attack.
Enrique, a former team-mate of Guardiola's for Barca and Spain, expects the contest to be one of high quality.
"I can not imagine a better game for any football fan in general", said Luis Enrique.